How to use antibody in a sentence

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Sentence Examples All 79 patients were seronegative for the HIV antibody by the enzyme-linked immunosorbent assay. Children with autism had 20 percent higher concentrations of antibody producing B cells and 40 percent more natural killer cells. Twenty microliters of each antibody was added to 100 L of blood, and the mixture was incubated at room temperature for 15 minutes. Harris hematoxylin was the counterstain for the remainder of the antibody reactions. I took those sera down to Melbourne with me and tested them to see if any of them had antibody to this newly discovered tick typhus organism. The percentage antibody prevalence was calculated using the ratio of positive sera to the total sera tested in each age group. Controls included omitting the primary antibody, using control rabbit serum as primary antibody, and omitting the secondary antibody. Polyclonal anti-RIP1 antibody was purified over a column of recombinant His-tagged proRIP1 coupled to cyanogen-bromide activated Sepharose. She says each antibody in a panel attaches to a different site on the cytokine, allowing accurate measurement. In addition, it is possible to use an animal polyclonal antiserum for capture and a human IgE antibody containing serum for detection. One should note whether the antibody is polyclonal or monoclonal and also the species and isotype of the primary antibody. The presence of antinuclear antibodies was tested by indirect immunofluorescent antibody staining of fixed cells. We therefore evaluated an indirect immunofluorescent antibody assay for the diagnosis of melioidosis. Spindles were detected by the indirect immunofluorescence method using antitubulin antibody. The specificity of this antibody towards wood peroxidases was confirmed by immunoblotting. In all the experiments on native titin, the molecule was attached to two beads, each labeled with an antibody to a different epitope. Once B cells have come into contact with an antigen they proliferate and differentiate into antibody secreting cells. Also, we emphasize that not all individuals with high anti-GAD antibody levels necessarily develop the clinical disease. Health status of the cow is also considered important in determining antibody response when producing hyperimmune products. The presence of parathyroid tissue was confirmed by positive immunoreactivity with a monoclonal antibody to parathormone. Show More Sentences It does not appear to be a classic heterophile antibody, nor is it a paraprotein. High antibody titres may indicate current or previous tubal infection, and both partners should be treated with an appropriate antibiotic. This antibody labels the nuclei of the male embryos, revealing a single subnuclear spot that corresponds to the X chromosome. The patient was positive for hepatitis C and herpes simplex virus 1 and 2 antibody. An antibody manufactured at The University of Queensland will be used in world-first human Hendra virus clinical trials starting this month. Infection is cleared, usually within 2-3 weeks, by antibody opsonization and macrophage clearance. The data suggests that they contain a surface antigen that showed antibody responses which were both opsonic and potentially protective. A well-known practical application of this observation is the use of microbe-derived adjuvants to increase antibody responses. Infection is diagnosed more accurately by serum antibody tests or molecular polymerase chain reactions. We tested one further antibody that has been successfully used in geese but it did not give satisfying results in stonechats. The mother was O Rh-positive, antibody screen negative, rapid plasma reagin nonreactive, hepatitis B surface antigen negative. The catalytic antibody technology can localize the delivery of a cytotoxic drug to a specific cell or cancer type. Breakthrough infections and chronic carriage were clearly and strongly related to peak antibody concentrations. Not all patients who develop the antibody will undergo red blood cell hemolysis. If the HLA antigen and specific antibody bind, and complement is added, the cells in that well will be killed. This novel vaccine induces strong cellular and antibody immune responses in animal models, including non-human primates. IgA antiendomysial antibody testing has been reported to be 100 percent sensitive in patients with total villous atrophy. The remainder of the antibody molecule is more constant between different antibodies. Studies conducted in later years have shown that anamnestic antibody response exists within a group and is not related to all the subtypes. It was necessary to supplement blood with human fibrinogen because the antibody does not cross-react with canine fibrin. Show More Sentences An antibody is any protein that is released in the body in direct response to infection by an antigen. An antibody is a protein which recognises a foreign molecule, known as an antigen. Secondly, this membrane sheet is treated with a solution containing an antibody to the protein of interest. Individuals with the same history of sensitization have similar patterns of antibody specificities to latex proteins. When the synthetic peptide was used as the antigen, a monoclonal antibody was obtained. Another challenge is dealing with exacerbation or crises in the disease when the antibody titer reaches very high levels. Is the antibody test a false positive or the histological examination a false negative? An antibody against botulinum toxin is available, which binds to the toxin and inactivates it. There is no endogenous peroxidase activity or nonspecific binding of the secondary antibody in the paraffin-embedded sections. Presently the company is developing a biosimilar of the antibody, a drug with dramatic therapeutic effects for rheumatoid arthritis. Alternatively, serum antibody may be transuded into tracheal secretion or reach mucosal surface in inflammatory exudates. Patients with lower antibody titers to varicella after vaccination also had an increased rate of breakthrough infection. For example, though I had chicken pox decades ago, I still have antibody to chicken pox. She was not known previously to be HIV infected but on testing was found to have antibody to the virus. It had become a laboratory standard or reference strain for raising antibodies and for challenge in virus neutralization test to detect and assay antibody in serum. The antibody positive cells were cloned by limiting dilution method. The Finnish researchers had made these antibody fragments to specifically latch on to only one mirror-image form, or enantiomer, of a test molecule. The clear cells possessed abundant finely reticulated clear cytoplasm, which was highlighted by trichrome stain and immunostaining with antimitochondria antibody. After rewashing, the primary antibody was applied for 1 hour. Antigen expression can be augmented by concomitant treatment with lymphokines if necessary, which facilitates antibody recognition of the target cancer cell. Show More Sentences Because of the low avidity of the antibody, HSF1 needed to be enriched prior to western blot. We can make micro-organisms evolve very quickly in a test tube, by applying an appropriate selective pressure like an antibody. After oviposition, the parent females were screened for the presence of virus by fluorescent antibody technique as mentioned below. All the conjugated peptides were injected together in white rabbits as antigens for antibody production. Diesel particulates increase the formation of the allergic antibody and can also increase sensitisation to commonly encountered allergens in the air. The antibody response was termed as group specific, species specific or cross reactive depending on the comparative antibody titres obtained against different antigen pools. Protective antigen of Bacillus anthracis is the central moiety of the anthrax toxin complex and it elicits antibody response useful for serodiagnosis of the disease. We attempted to assess the specific consequences of topographical changes by selective manipulation of this parameter with neutral K20 antiintegrin antibody. Fluorescence micrographs of radicle cells of dry seeds and seedlings of Medicago truncatula, labelled with tubulin antibody and with a fluorescent secondary antibody. It is given by injection and stimulates serum IgM, IgG, and IgA, but not secretory IgA, immunity being induced by antibody transuding into the oropharynx. Acid-fast and parasite trichrome stains of lung biopsy specimens were negative, as were direct fluorescent antibody stains for legionella and pneumocystis carinii. They can stick to the cells for weeks and researchers have discovered that the usually bent antibody will unbend to secure itself to the mast cells. The reason for this is because pain and burn are more directly invasive, and electric moxibustion, without using moxa, can enhance antibody production. By western blot assays the antibody was monospecific against the Mn-SOD of pea leaf extracts. Laughter Therapy increases the antibody levels in the mucous membranes of the respiratory passages, thereby reducing the frequency of chest infections. In our study antibody concentrations in uninfected older teenagers stabilised over the previous four years, perhaps as a result of increased exposure by the sexual route. An antisynthetase antibody, when positive, may help confirm the presence of an inflammatory myopathy. Chromatin was sheared by sonication, and DNA associated with either CLF1 or ORC1 was separately co-immunoprecipitated using an anti-HA antibody. Extraction of total soluble protein from tobacco leaves and immunoblotting using the above antibody was carried out according to standard protocols. This approach is valuable for rapidly screening antibody specificities and assessing protein orientation needed for optimal presentation of immunogenic determinants. Show More Sentences The use of antilymphocyte antibody therapy for immunosuppression also enhances the likelihood and severity of infection in susceptible recipients. Immunogenicity does not necessarily imply opsonising antibody production. Weakened resistance to infection is caused by decreased antibody and complement production, leukocyte phagocytosis and intracellular killing, and macrophage phagocytosis. Most scientists working with the new inhibitors and monoclonal antibody treatments acknowledge they will be used in combination with chemotherapy for years yet. If the conjugated antibody binds to surface proteins on healthy cells, those cells are doomed, as the conjugate will be internalized and digested in the normal fashion. However, studies have shown that native DNA might actually be the cross-reacting antigen whereas modified nucleic acid polymers stimulate antibody response. Moreover, infected infants had low levels of specific antibody to the infective serotype. The affinity between the mutually complemental antibody and receptor was described by a weighted affinity matrix. To test cats for feline leukemia virus and immune deficiency virus, vets check for the presence of the virus itself, not the antibody levels. After a second overnight incubation and washing, the detection antibody is added. A negative result of an antibody test, particularly during the first week of illness, may indicate that the patient does not have infectious mononucleosis. At one year, if the patient is clinically and biochemically euthyroid and a thyroid-stimulating antibody level is not detectable, therapy can be discontinued. Plasma cells then make excess gamma globulin antibody immune proteins that latch onto specific invaders. He soon had a rough draft of a manuscript about how an antibody might be formed and the physical-chemical basis of its specific reaction with antigen. A monoclonal antibody to influenza nucleoprotein was purchased from QED Biosciences. The importance of these factors is supported by the findings that thicker skinfolds are associated with a lowered antibody response to vaccines. These control experiments confirmed that the antibody penetrated well in all the samples studied. So it's feasible to raise enough antibody there to either completely block or very substantially attenuate the effects that nicotine would have. Testing for HIV infection is usually done by detecting the presence of an antibody to the virus. This can be done only if the antibody workup is completed prior to the initiation of surgery. Show More Sentences This assay is a highly quantitative and direct measure of antibody response to a specific antigen. If infection is established, this agent will have a lesser ability to disrupt the complexes because of high antibody avidity. This antibody is found in body fluids such as tears, saliva, and other bodily secretions. The candidates are both immunotoxins comprising an antibody fragment that targets the CD22 receptor on B-lymphocytes fused to a toxin molecule. An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis. Due to advances in humanisation technology, antibody therapies have rapidly come of age as the most important new treatment technology. Also, MVA allows offering reliable services such as epitope mapping, antibody analyses, immunogenicity assessment, etc. Immunoassays with protein fractions revealed the antibody specificity to the prolamin and glutelin fractions in the respective grains. The specificity of each antibody was immunochemically checked by two-dimensional Western blotting against all of the other analytes prior to use. No immunoreactivity was detected when a monoclonal antibody MiTF was used as the primary antibody in the negative control staining. Immunotoxins made with the antibodies and antibody fragments of the invention have improved cytotoxicity to CD22-expressing cancer cells. Divergent effects of low versus high dose anti-TGF-beta antibody in puromycin aminonucleoside nephropathy in rats. The anti-gliadin antibody showed comparatively strong reactivity to gliadin, compared with the glutenin fraction. Red knots, sanderlings, and laughing gulls were rarely infected, but dynamic changes in antibody prevalence differed among species. ThromboView uses a clot-binding monoclonal antibody attached to a radiolabel. Viral levels began to drop within three days of treatment with the PDL-1 antibody, which was administered intranasally. So in recent years, many scientists have given up on antibody approaches to HIV vaccines or treatments. Staining was not seen in serial sections stained with the isotype antibody or with no antibodies. The percentage of events reactive with each monoclonal antibody was determined, setting thresholds with isotypic controls. In an additional experiment, the primary antibody was replaced with isotypic mouse immunoglobulin IgG2b at the same concentration. Show More Sentences Variation of antibody titers against M2e in IVIGs may be geographically dependent. Evibodies are only one tenth the size of an antibody and can therefore be manufactured more economically. The researchers also found that injecting amniotic fluid with an antibody that blocks SP-A delays labor by 1 day in mice. Technologies, creating a superior antibody molecule with enhanced ADCC and CDC activities. Two different hollowfibre bioreactors were used for the production of a human monoclonal antibody for clinical use. The antibody test found osteocalcin in the bones of hadrosaurs, a ceratopsian, and a sauropod dinosaur. Adalimumab is an IgG monoclonal antibody specific for TNF-alpha, thereby blocking its interaction with cell surface TNF receptors. Subsequently, predicted antibody activity titres were determined directly from the standard curve by solving the regression line equation. The mean and median antibody titres against the STn-bearing mucin OSM were higher in the patients treated with the new formulation. If an antibody is suspected, potential donor units must first be screened for the corresponding antigen by phenotyping them. Comparison of tissue transglutaminase-specific antibody assays with established antibody measurements for coeliac disease. Briefly, the brain sections were washed of cryoprotectant and placed into primary antibody solutions for GFAP or IBA-1 for 24 hr. Further antibody and serology testing of anti microsomal antibodies, thyroglobulin, Lyme serology, and perineoplastic antibodies were negative. In granulomatosis with polyangiitis, there are conflicting data on the ability of anti-proteinase 3 antibody levels to predict clinical relapses. Study showed that severe hemolytic anemia after childbirth was due to isoimmunization caused by an irregular antibody. That underproduction gins up a stronger antibody response from flu vaccines, researchers report in the December PLoSPathogens. Immunoselection involves the use of an antibody or a collection of antibodies. The results of the C-antineutrophil cytoplasmic antibody test, Mantoux test, and chest x-ray were normal. The antigen, usually a protein or carbohydrate made by an infectious agent, is bound by the antibody. The test works by taking a small blood sample that is analyzed to detect the presence of an antibody when the body is responding to an allergen. Show More Sentences British researchers found that some new antibody drugs work by engaging the garbage disposal system that exists in cells. Anti-parietal cell antibody test, gastroduodenoscopy and endoscopic biopsies were also performed in patients with Cbl deficiency. These tests are based upon the ability of an antibody to bind specifically to an antigen. No notable antibody reactivity was found to the noncitrullinated control peptides. Jacques Benveniste and his team's work studying human basophil degranulation in the presence of extremely dilute antibody serum. The precleared lysate was then preincubated with anti-phycocyanin antibody for 1 hr at RT before adding the cyanobacteria lysate. Unique Physico-chemical properties of Japanese B encephalitis antibody virus haemagglutination. Paper forms contained an individual check box for IgM HAV testing but did not contain a check box for total HAV antibody. The tissue sections were treated with anti-Histag antibody with appropriate secondary antibody with the counterstaining of hematoxylin. Elusys develops antibody-based therapies using proprietary technologies in Heteropolymer antibody chemistry and complement biology. Rituximab is a monoclonal antibody against CD20 antigen expressed on B-lymphocytes. Agonist antibody for TNFRII but not TNFRI were toxic alone and potentiated NMDA receptor-dependent toxicity. Inflectra is a chimeric humanCaemurine monoclonal antibody that binds with high affinity to both soluble and transmembrane forms of TNF alpha but not to lymphotoxin alpha. We developed a lectin ELISA that uses biotinylated AAL and a capture antibody specific for AGP to study the fucosylation on AGP in the acute phase response. AccretaMab platform consists of POTELLIGENT and COMPLEGENT Technologies, creating a superior antibody molecule with enhanced ADCC and CDC activities. Cerebrospinal fluid analysis was normal for cell counts, protein and glucose levels, oligoclonal bands, infectious agent and paraneoplastic antibody scanning. A decrease in anti-AChR antibody concentration may have been caused by CPB institution, hemodilution, and adsorption of antibodies to the pump components. Nevertheless, no connections were found between the levels of IgE and histamine caused by anti IgE antibody in healthy people as well as in patients with pollinosis. Remsima is the world's first biosimilar monoclonal antibody to be approved by the European Medicines Agency for the treatment of eight autoimmune diseases. The unique Universal phosphotyrosine antibody is among them. Show More Sentences The drug, rituximab, acts by suppressing antibody production within the immune system and breaking a key part of the cycle that leads to arthritic inflammation. The cell-mediated immune response is critical for controlling such pathogens because their intracellular location shelters them from antibody binding. The treated lab animals had fewer immune cells in their central nervous systems, less myelin damage, and fewer symptoms compared to a control group not given the antibody. Further specificity analysis reveals a subset of functional antibody clones capable of recognizing the rodent ortholog of the target, enabling in vivo pharmacology studies. Hepatitis serology test results were negative, ceruloplasmin level was normal, and anti-mitochondrial antibody and anti-smooth muscle antibodies were negative. It is now able to offer new services, including antibody humanisation to supplement its antibody engineering, antibody expression and hybridoma sequencing services. A key differential diagnosis is Goodpasture disease, which was excluded in our patient by a negative antiglomerular basement membrane antibody test. The value of anti-calretinin antibody in the differential diagnosis of normal and reactive mesothelia versus metastatic tumors in effusion cytology. Red blood cells were lysed using hypotonic shock, and leukocytes were subjected to surface CD14 labeling using phycoerythrin-conjugated CD14 antibody. The SDS-PAGE gel of HMD and BDDGE treated group, which depicted characteristic bands of collagen, was used as a model to assess the antibody binding in the immunoblot. Other tests are more sensitive in that they produce higher antibody titres but they do not detect substantially more seropositive individuals in a population. Ewes are often revaccinated annually about 3 weeks before lambing, to provide high antibody concentrations in colostrum during the first several hours after lambing. Target proteins were identified using primary antibodies and immunoprobed using a horseradish peroxidase-conjugated secondary antibody and chemiluminescent substrate. This form was marked by a fever that occurred after the usual incubation period and could be confirmed only by antibody studies or, rarely, by virus isolation. This strategy is based on blocking the CGEN-15001T immune checkpoint protein, which we have demonstrated is expressed on cancer cells, using a therapeutic monoclonal antibody. The objective is to optimize Fc receptor mediated antibody function. We found that, similar to TIMP-1 antibody, the capture antibodies for tPA, DPP-4, and MME did not cause background binding to the selected lectins. Even in earlier studies, it has been proved that immunization with herbal drugs may produce antibody response against snake venoms in experimental animals. We previously developed an immunoassay for CP, a ferroxidase that plays a role in copper and iron metabolism, and characterized the antibody pair for this blood protein. When the antibody was applied to healthy immature marrow cells, it caused them to mature into blood-platelet-producing cells called megakaryocytes. Show More Sentences According to the researchers of Duke University, the new antibody works by targeting the voltage-sensitive sodium channels in the cell membrane of neurons. That's in large part because one of the most common features of the disease is the presence of an antibody called rheumatoid factor in a person s blood. The Venereal Disease Research Laboratory test result was positive, and a fluorescent treponemal antibody absorption test result was strongly reactive. In short, their paper concluded that less than a single molecule of antibody could trigger an immune response in human basophils, defying the physical law of mass action. As a result, Kirin will hold Hematech's rights primarily related to polyclonal antibody production, along with the development and marketing rights already held by Kirin. Enzyme-linked immunosorbent assay for measurement of IgG antibody to Molluscum contagiosum virus and investigation of the serological relationship of the molecular types. Each specimen's event clusters were considered positive or negative when compared with the degree of the same specimen stained with the isotypic control antibody. But, because so many kids get strep throat and antibody titers often stay elevated for 3-9 months after an acute infection, many argued that there was no proof of causation. With the genes in place, the new strain of tobacco produced the antibody in its leaves and secreted the antibody from its roots into the surrounding hypotonic growth medium. If there is no antibody present, an immediate spin crossmatch or computer assisted crossmatch is performed where the recipient serum and donor rbc are incubated. The original article listed three proteins, w-5 gliadin, g-3 hordein, and g secalins that were implicated in the production of specific antigliadin antibody reactions. The expression of palivizumab in plants resulted in self-assembly of the appropriate antibody quaternary structure, which was then recovered from the plant tissue. Supra dietary levels of vitamins C and E enhance antibody production and immune memory in juvenile milkfish, Chanos chanos to formalin-killed Vibrio vulnificus. Examples from Classical Literature One function of the free receptor, the antibody, is always to unite with the chemical substance which caused it to be formed. The antibody could be synthesized and one could attack any epidemic with confidence. A quick test-run showed that the antibody was also being regenerated. It is evident that some sort of an antibody results from the first protein injected and that it is specific for its own antigen. The kind of antibody and the manner of its action will differ with the different kinds of antigens used. That last checkup showed an antibody titer entirely too high for safety. We examined umbilical cords of 66 infants whose mothers had positive RPR and fluorescent treponemal antibody absorption tests. Studies have shown that heterologous neutralizing antibody titers are inversely correlated with severity of a second infection. I should say the antibody titer has reached the danger point. All we've done was inject an antibody against a specific virus. We present a case of paraneoplastic cerebellar ataxia associated with anti-Yo antibody due to an underlying gynecologic malignancy. People with platelet clumping have an antibody in their blood that recognizes these changes, binds to the platelets, and provokes clumping. Find more words! 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What is the opposite of antibody? Words that rhyme with antibody What is the plural of antibody? What is the noun for antibody? Translations for antibody Use our Sentence Generator Nearby Words antibodies antiblack antibiotics antibiotic resistance antibiotic antibiosis anti-british antibug antibullying anti-bullying antibusiness antibusing 8-letter Words Starting With a an ant anti antib antibo antibod