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What is another word for substance abuse?

Hint: See synonyms for addiction and abuse.

Dependence on illegal drugs or substances
“Perhaps the most obvious issue is the resumption, continuation, or worsening of substance abuse.”
Dependence on alcohol
“With reports of shattered guitars, groupie mayhem, and determined substance abuse, this new offering comes as something of a surprise.”
Dependency on drugs, especially which are illegal or improperly procured
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