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What is substance abuse?

What is substance abuse? Here are some definitions.

Noun
  1. An overindulgence in and dependence on a drug or other chemical.
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With reports of shattered guitars, groupie mayhem, and determined substance abuse, this new offering comes as something of a surprise.
For adolescent boys this risk may rise if the depression is accompanied by conduct disorder and alcohol or other substance abuse.
The importance of identity changes is well documented in literature on substance abuse recovery.
But in between campaigns, the Canadian Inuits have stunning rates of suicide, substance abuse and disease.
Ten days later the lawyer was committed to a state mental institution for substance abuse and was eventually disbarred.
Perhaps the most obvious issue is the resumption, continuation, or worsening of substance abuse.

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