| The next to last step in this chain is the activation of the circulating proenzyme prothrombin into its active form, thrombin. |
| In the assay, the addition of thrombin to citrated plasma causes the conversion of fibrinogen to fibrin, yielding a stops bleeding much quicker. |
| This complex activates prothrombin to thrombin in the presence of calcium ions. |
| This white, fibrous protein is made when thrombin, an enzyme found in blood, reacts with fibrinogen, a protein in blood. |
| It converts fibrinogen to fibrin, and unlike thrombin, is unaffected by heparin. |
| Contact with tissue factor triggers the coagulation cascade, resulting in the conversion of prothrombin to active thrombin. |
