| No tachyphylaxis and no rebound phenomenon were observed, and giving the drug twice a day had no advantage over a once a day regimen. |
| These effects on histamine secretion and on protein phosphorylation were rapid in onset and both showed tachyphylaxis. |
| The rate of development of tachyphylaxis to the pressor effect was found to be greater with pseudoephedrine than with ephedrine. |
| Giving methotrexate concurrently, however, suppressed tachyphylaxis, probably by preventing the production of human antichimeric antibodies. |
| Total renal blood flow was not affected, and there were no signs of increased blood methemoglobin concentrations or tachyphylaxis. |
| This spirometric improvement was maintained throughout the 13-week period without any evidence of tachyphylaxis. |
