Induced cross resistance to other drugs, like sulfadoxine and pyrimethamine, an antimalarial treatment, is a major concern. |
Prophylaxis with trimethoprim-sulfamethoxazole or dapsone plus pyrimethamine is recommended. |
The condition responds well if treatment is started early, and a combination of sulphadiazine and pyrimethamine is the treatment of choice. |
Several other drugs have been evaluated, including tetracycline, primaquine, sulfadiazine and pyrimethamine. |
Small colony mutants 540 and a subclone of 540 were obtained from cells exposed to pyrimethamine. |
A case report suggests carnitine deficiency was induced in a patient receiving sulfadiazine and pyrimethamine. |