In addition, polysomy 17 was noted in 25 cases, of whom 14 were amplified, nine were not amplified and 2 were equivocal. |
In order to avoid misinterpreting chromosome 17 polysomy as HER2 gene amplification, the use of a CEN 17 probe is recommended for more accurate HER2 status assessment. |
On the other hand, having Y chromosome polysomy has other effects than masculinization. |
The incidence of polysomy of chromosome 17 varies from 10-50 per cent depending on criterion used to define the polysomic state. |