In humans, you can get a single point mutation, and a vaccine that's 99.99percentt related won't protect you. |
Arrows indicate the position of the point mutation and the corresponding nucleotide on the wild-type sequence. |
To introduce a point mutation the gene must be cloned, the desired point mutation must be generated within that clone, and an I-SceI site must be inserted. |
So tell me how a simple point mutation changes the information content of the gene. |
We can only estimate the relative expansion slippage rates and contraction slippage rates compared to the point mutation rate. |
High selective discrimination against point mutation of bacteria at hot-spot region was observed. |