| At the level of populations, the scaling of mutational effects with pleiotropy can be addressed via the neutral theory of molecular evolution. |
| These salutary effects of ezetimibe on statin levels presumably enhance the beneficial effects attributed to statin pleiotropy. |
| Conditions for the selective maintenance of stable polymorphisms by antagonistic pleiotropy are quite restrictive. |
| These studies demonstrated that performance and preference of host-plant use may be genetically associated by linkage or pleiotropy, and evolve as correlated traits. |
| One of the best-documented cases of pleiotropy is the gene associated with sickle-cell disease. |
| If gene effects on the trait and fitness are correlated due to pleiotropy, genes of large effect on the trait will remain at much lower frequencies. |
