| These results will provide a better insight into understanding which metabolite is important in benzene leukemogenesis. |
| Others view meperidine as inappropriate because the metabolite if meperidine, normeperidine, causes analeptic activity. |
| This involves gene transfer of an enzyme into tumour cells, which converts an inactive prodrug into a toxic metabolite, leading to cell death. |
| Yabuki et al. described a novel metabolite with a different ring-opening pattern leading to a cyanamide. |
| The downstream methionine metabolite taurine is necessary for amino acid and bile acid conjugation, and acylation reactions. |
| It is of particular concern with agents that are metabolized to an active metabolite with significant renal excretion. |
