| Under appropriate culture conditions, the megakaryocyte burst-forming cell can develop into 40 to 500 megakaryocytes within 1 week. |
| The drug, megakaryocyte growth development factor or MGDF, was being tested in cancer patients receiving chemotherapy. |
| Bone marrow biopsy and other hematologic tests were consistent with agranulocytosis and marked erythroid hypoplasia of the megakaryocyte type. |
| Bone marrow aspiration cytology revealed normal cellularity, with myeloid, erythroid, and megakaryocyte cell lines present. |
| As the megakaryocyte matures, small fragments break off and are released into the blood stream. |
| Thus, thrombopoietins are active in diseases with BM megakaryocyte mass such as ITP and thrombocytopenia following nonmyeloablative chemotherapy. |
