The median time to laxation was approximately 30 minutes after administration of methylnaltrexone. |
There are no data regarding the amount of fibre needed for normal laxation during the first 2 years of life. |
No laxation response was observed in the 11 patients receiving placebo. |
Neither study was designed to assess the impacts of daily laxation treatment. |
One patient did not respond due to faecal impaction but subsequently experienced laxation after manual disimpaction. |
Those patients treated by conventional means eventually produced laxation after a further 3 to 5 days. |