| Individuals with GSD-1a display hypoglycemia, hepatomegaly, nephromegaly, hyperlipidemia, hyperuricemia, lactic acidemia and growth retardation. |
| Other less commonly reported laboratory abnormalities were: Elevated fasting blood sugar, elevated CPK, and hyperuricemia. |
| Joint damage in hyperuricemia causes classical attacks of gout but tophi may also develop in cartilage, tendons and other tissues. |
| Only a minority of patients with hyperuricemia develops tophi and gouty arthritis. |
| Extremely high doses of exogenous pancreatic enzymes have been associated with hyperuricemia and hyperuricosuria. |
| Right now, it is estimated that 15 million to 20 million Americans have elevated uric acid levels, known as hyperuricemia. |
