| Their clinical symptoms were primarily hyperkeratosis and hyperpigmentation, which are well-recognized signs of arsenicalism. |
| Most leukoplakias are caused by hyperkeratosis or a thickening of the outer keratin layer. |
| The term hyperkeratosis is also used to describe the hypertrophy of the corneous layer of the human skin. |
| Corns and calluses result from hyperkeratosis, a normal physiologic response of the skin to chronic excessive pressure or friction. |
| The most common pattern of oral disease reveals a reticular network of white hyperkeratosis on the buccal mucosa. |
| Skin biopsy typically reveals hyperkeratosis and follicular plugging, with superficial and deep lymphocytic infiltrates. |
