More recently, however, several cloned chromosome 4 genes have been localized using in situ hybridization. |
Sample workup, hybridization, and analysis were performed as described previously. |
In situ hybridization to polytene chromosomes confirmed that each insertion was in a typical euchromatic, banded region. |
High-level amplification was revealed by comparative genomic hybridization. |
Conversely, it is well known that cracids can hybridize very easily in captivity, though natural hybridization has not been reported in the wild. |
As far as i know, people usually produce subclones, map them by hybridization and then start shotgun cloning and sequencing many small clones. |