Constitutive isoforms of NOS are dependent on intracellular concentration of calcium and calmodulin. |
High levels of intracellular calcium allow calmodulin to activate the myosin light chain kinase that facilitates muscle contraction. |
One of the subunits of this enzyme is the ubiquitous protein, calmodulin. |
These mechanisms include allosteric regulation, regulation by reversible covalent modification and regulation by control proteins such as calmodulin. |
A trivial reason explaining how both step sizes can be the same, is that the labeled calmodulin is bound to the catalytic domain. |
As examples, we have probed yeast proteome chips with calmodulin and six different phospholipids. |