In September, Hiscox suggested that a drug known as ouabain, traditionally used for severe heart disease, could reduce the virus's replication. |
An unexpected result is that ouabain and amiloride, which do not react directly with cytochrome c oxidase, modify significantly the absorption of the photoacceptor. |
The rodent alpha-1 isoform is highly resistant to the binding of ouabain, and this resistance is due in large part to two charged amino acids in the H1-H2 region of the protein. |
We treated rat lungs with amiloride and ouabain, respectively. |
The alpha-2 and alpha-3 isoforms are primary candidates for mediating the brain OLS effects because they are the most sensitive to ouabain. |
The OLS is thought to closely resemble the plant-derived substance ouabain. |