| Perhaps the best evidence of topical aminoglycoside ototoxicity is seen when intratympanic gentamicin is administered for the treatment of incapacitating Meniere's disease. |
| Her chest x-ray and systemic symptoms were improving, but she was experiencing some ototoxicity. |
| The risk of ototoxicity is not as much of an issue with the intact tympanic membrane. |
| The ototoxicity, however, is permanent and is due to the death of the outer hair cells in the organ of Corti of the cochlea and type I sensory cells in the vestibular organ. |
| The safety profile of the formulation is generally favorable, with no demonstrable ototoxicity, nephrotoxicity, bone marrow suppression, or cardiovascular adverse effects. |
