| The project goal is to explore the role of C-reactive protein in white matter damage in a laboratory model of chronic hypoperfusion. |
| This, coupled with splanchnic hypoperfusion, necessitates early and aggressive enteral feeding to decrease catabolism and maintain gut integrity. |
| It is usually initiated when systolic blood pressure falls below 90 and there is evidence of hypoperfusion. |
| Microvascular vasoconstriction is the underlying process and is precipitated by splanchnic hypoperfusion due to depressed cardiac output or renal or hepatic disease. |
| This is not easy, as too little fluid will cause hypoperfusion whereas too much will lead to oedema that will cause tissue hypoxia. |
| The beta blocker dose should be reduced if the decrease in heart rate is symptomatic or is associated with hypoperfusion or higher than first-degree atrioventricular block. |
