Studies in simian cell lines transfected with human alpha satellite sequences showed that these repetitive regions could form de novo centromeres on existing chromosomes. |
Telomeres and centromeres typically contain few genes but are important for the function and stability of chromosomes. |
We conclude that chromosomes with damaged centromeres fail to correctly attach to the spindle, thus producing MN and monosomy. |
The pertinent variable in this form of meiotic drive is the presence of differing numbers of centromeres on paired homologous chromosomes. |
Two of those contained repetitive sequence and hybridized to the centromeres of the polytene chromosomes. |
The sizes of the two centromeres from the homologous chromosomes are different. |