What is the opposite of most insignificant?

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Adjective Opposite of superlative for too small or unimportant to be worth consideration heaviest noteworthiest deepest heftiest mightiest seriousest biggest greatest largest gravest strongest weightiest extremest hugest severest highest powerfullest most significant most important most material most meaningful most consequential most considerable most substantial most essential most momentous most vital most appreciable most exceptional most historic most impressive most outstanding most earthshaking most sizable most generous most marked most remarkable most striking most climacteric most crucial most extensive most noticeable most valuable most emphatic most impactful most notable most especial most eventful most sensational most critical most fundamental most monumental most pronounced most sensible most distinctive most extraordinary most major most large-scale “A blood test will show a significant reduction in the hemoglobin content of the red blood cells and an increase in the size of the cells.” Find more words! 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Use our Antonym Finder Nearby Words most insincere most insincerely most insipid most insipidly most insistent most insociable most insightful most insidious most inside most inseparable most insentient most insensitively