“From the e18 conceptuses, brain, liver, and the placenta were dissected for methylation analysis.”

“In mammals, methylation is required for essential developmental programs including X chromosome inactivation in females and genomic imprinting.”

“Important mechanisms for epigenetic alteration of gene expression include DNA methylation and histone acetylation.”

“The CpG island methylator phenotype is characterized by DNA hypermethylation in the promoters of tumor suppressor genes with silencing of transcription.”

“About half of the promoters of human genes are embedded in CpG islands, so this phenotype in tumor DNA is called the CpG island methylator phenotype.”

“Further studies into the methylation status of this promoter region would provide insight into the CpG island methylator phenotype of these tumours.”

“The restriction enzyme and its corresponding methylase constitute the restriction-modification system of a bacterial species.”

“The maintenance methylase will then add methyl groups to all the CGs opposite the existing methyl groups to restore a fully methylated double helix.”

“Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail.”