“What triggers receptor autoimmunization in DCM is unclear.”
“Thus, binding of a statin to the enzyme could create structural change that alters the enzyme's conformation or intracellular metabolism to promote autoimmunization.”
“The coincidence of highly prevalent, high-titer IFN autoantibodies in patients with thymic epithelial tumors or genetic defects in AIRE suggests parallel mechanisms of autoimmunization in the APECED thymus and thymomas.”