(idiomatic) An informal greeting asking the other person what has recently happened in their life. A typical response might be, "Not much, you?". At times the greeting may not be literal and might just be used as a synonym for hello or what's up.
(sarcastic) A rhetorical request for some real news, on hearing a report that wasn't news because it was predictable. Implies that the situation is and always has been unsatisfactory.