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What is a thing-in-itself?

What is a thing-in-itself? Here are some definitions.

Noun
  1. (philosophy) A thing as it is independent of any conceptualization or perception by the human mind, postulated by practical reason but existing in a condition which is in principle unknowable and unexperienceable.
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Examples
Soon Hegel and Fichte came along and dumped the thing-in-itself, leaving nothing but pure mind.
Schopenhauer's position on whether the thing-in-itself is Will consequently presents some interpretive difficulties.
Nevertheless the thing-in-itself is a problematic conception and of a limiting or negative use merely.
And in making such reference Science is thinking of the thing-in-itself.
The thing-in-itself, accordingly, indicates the limit and not the object of knowledge.
Similarly, Lange reduced science to the phenomenal level and repudiated the thing-in-itself.

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