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What does substitutionally mean?

Looking for the meaning or definition of the word substitutionally? Here's what it means.

Adverb
  1. As a substitute.
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There were 15 variable sites across the five loci, 12 of which differed substitutionally between the two sequences of 'I'iwi and 'Apapane.
It was speculated that boron and nitride atoms may be substitutionally incorporated into graphite layer.

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