In 1994, saquinavir, the first anti-H. I. V. protease inhibitor, was tested in clinical trials. |
These were followed by indinavir with ritonavir, saquinavir with efavirenz, and saquinavir with ritonavir. |
Carcinogenesis: There was no evidence of carcinogenic activity after the administration of saquinavir mesilate for 96 to 104 weeks to rats and mice. |
Examples of protease inhibitors include ritonavir, saquinavir, and indinavir. |
One person was just on Kaletra and saquinavir with no nucleosides, and the other was on nucleosides but had high-level resistance to them. |
As a result of the study, the manufacturer of saquinavir is recommending that patients taking ritonavir-boosted saquinavir should not receive rifampin because of the risk of liver damage. |