The broad spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. |
The DNA polymerase recognizes the base sequence to which it must bind and align the ribonucleoside triphosphates with the complementary bases. |
The method uses an oligonucleotide having a sequence essentially identical to a guide sequence found in the 5 flanking exon and terminates with a 3 ribonucleoside. |
Efficiency of digestion was confirmed by HPLC against ribonucleoside standards. |