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What is a reagin?

What is a reagin? Here are some definitions.

Noun
  1. (biochemistry) An antibody.
  2. (archaic) A substance elaborated by the spirochetes of syphilis and yaws, having the property of uniting with lipoids, and of fixing complement.
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Examples
Blood work, including rapid plasma reagin for syphilis and heavy metal screening, had been reported as normal.
Even without a confirmatory rapid plasma reagin test or darkfield examination of the gummatous discharge, the diagnosis of secondary syphilis was obvious.
Tests for human immunodeficiency virus and borreliosis were negative, and her rapid plasma reagin test was nonreactive.
The results of a VDRL test and rapid plasma reagin were negative.
This reaction is the basis of traditional nontreponemal tests such as the VDRL test and rapid plasma reagin test.
In RPR and VDRL the detection of syphilis reagin is based on the reaction of reagin with a lipid antigen usually extracted from beef heart to produce a visible clumping, or flocculation, within the serum.

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