Though it normally help cells mature, c-jun can also act as a proto-oncogene, Timblin explains. |
The Genentech researchers validated 392 somatic SNVs in coding regions, including one in the KRAS proto-oncogene. |
Further investigation showed that the vector had inserted the gene near a proto-oncogene, which led to uncontrolled growth of the T cells. The clinical trials were put on hold until a safer method can be designed and tested. |
The src gene, then, was really a cellular oncogene, or proto-oncogene. |
A proto-oncogene may be converted into an oncogene through a single alteration of a nucleotide. |
Proto-oncogene tyrosine-protein kinase 1. proto-oncogene B-Raf. |