The highest expression of sclerostin throughout the adult skeleton has been observed in hypertrophic chondrocytes and osteocytes. |
This communication network serves for transport of nutrients, waste products, and signaling molecules from the vascular system to the osteocytes and vice versa. |
These cells, the osteocytes, have long extensions which pass down an interlocking network of canaliculi in the bone. |
By definition, the necrotic zone will be acellular, at least as far as osteocytes and bone marrow cells are concerned. |
Within the epiphysis of most sections, trabecular bone is frequently hypereosinophilic, and there is karyolysis and loss of osteocytes. |
Bone also contains nutritive cells called osteocytes. |