| Drs. Dixon and Sims have a unique expertise in studying osteoclast biology. |
| Our goal is to stop the osteoclast acid pump responsible for bone loss, without affecting acid pumps needed for other essential tasks. |
| Prevention of RANKL-RANK interaction inhibits osteoclast formation, function and survival, thereby decreasing bone resorption. |
| Lytic bone metastases in cancer patients are caused by increased osteoclast activity. |
| Levels of TRAP5b activity may be a useful indicator of osteoclast activity and hence bone resorption in primary osteoporosis and other diseases. |
| Ingesting enough of those crystals incapacitates the osteoclast, and prevents further deterioration of the bone. |
