It is assumed that an imbalance of both serotonin and noradrenalin neurotransmitters in particular causes depression or anxiety disorders. |
In experimental studies, trazodone is a weak inhibitor of noradrenalin re-uptake but is practically inactive against 1-dopa, histamine and acetylcholine. |
Chromaffin cells are potentially capable of releasing very small quantities of dopamine, a precursor to noradrenalin. |
In addition, in animals treated with Peptidea®, the rate of transport of adrenalin and noradrenalin was slower. |
Other well-known examples such as noradrenalin, serotonin and glutamate then gradually followed. |
At that stage, it was presumed that SPS was caused by noradrenalin over-activity. |