| Several studies have demonstrated that only the 5-nitrofurans are mutagenic and that derivatives with the nitro group outside the furan ring do not show mutagenic activity. |
| Though the mutagenic activity of ethylene thiourea is well documented, very little is known about the deleterious effects of zineb. |
| Halogens such as chlorine and bromine react directly with uracil, adenine, and guanine, giving substituted bases that are often mutagenic. |
| Lead is clearly not a powerful mutagen, nor is it consistently mutagenic among various test systems. |
| For example, many metals, like cadmium, lead, and mercury are toxic to humans and are mutagenic and carcinogenic. |
| Due to its extreme mutagenic potency, this compound constitutes an interesting model to study the mutagenic action of nitrofurans. |
