| The latter harbor the ortholog of the most frequently encountered human R350P desmin missense mutation. |
| Structural analysis of missense mutations causing isolated sulfite oxidase deficiency. |
| Thus, MGCD265 inhibits signaling through both wild type and mutant forms of Met and may benefit patients with cancers in which Met is activated due to missense mutations. |
| The genetic study conducted identified a pathogenic change C698G, a missense mutation in FH gene. |
| Protein modeling demonstrated that the missense mutation is damaging and may alter binding to ATP molecules. |
| If this change results in a functionally different amino acid, then a missense mutation may result. |
