| Second, the centromere is the focus for the formation of the kinetochore, where microtubules connect to the chromosomes during anaphase in mitosis and meiosis. |
| Importantly, each chromosome must construct one and only one kinetochore. |
| These include identification of the presence or absence of a kinetochore or centromeric DNA in the micronuclei. |
| The Caenorhabditis elegans kinetochore reorganizes at prometaphase and in response to checkpoint stimuli. |
| In addition, binding of the yeast CBF3 kinetochore complex to centromeric DNA was severely compromised in this mutant. |
| Likewise, within the paired kinetochores, one kinetochore represents the plus face, while the other represents the minus face. |
