| Integrins are an ancient group of animal adhesion receptors that attach cells to the extracellular matrix. |
| Transmembrane proteins, such as integrins, anchor cells to the substrate. |
| The activated PS2-containing integrins are clustered in basal plaques on each cell, but the PS1-containing heterodimers are not. |
| The integrity of the endothelial cell layer is also controlled by the tethering of the cells to the extracellular matrix through integrins. |
| In both mammalian and amphibian eggs, integrins have been proposed as putative sperm receptors. |
| The elucidation of the fly genome makes it relatively straightforward to generate and study mutations in proteins previously associated with integrins from other systems. |
