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What are integrins?

What are integrins? Here are some definitions.

Noun
  1. plural of integrin
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Integrins are an ancient group of animal adhesion receptors that attach cells to the extracellular matrix.
Transmembrane proteins, such as integrins, anchor cells to the substrate.
The activated PS2-containing integrins are clustered in basal plaques on each cell, but the PS1-containing heterodimers are not.
The integrity of the endothelial cell layer is also controlled by the tethering of the cells to the extracellular matrix through integrins.
In both mammalian and amphibian eggs, integrins have been proposed as putative sperm receptors.
The elucidation of the fly genome makes it relatively straightforward to generate and study mutations in proteins previously associated with integrins from other systems.

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