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What is in-and-in?

What is in-and-in? Here are some definitions.

Noun
  1. An old game played with four dice, a double being referred to as "in" and two doubles as "in-and-in".
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Examples
Few domesticated animals suffer so much from in-and-in breeding as swine.
The more well-bred the animals, the greater are the injurious effects of in-and-in breeding.
In fact, this in-and-in breeding seems one of the curses of village life, and a cause of stagnation and narrowness of mind.
Unceasingly did the drama practice the in-and-in breeding of sexual problems.
The red deer of the North Island represent the greatest case of in-and-in breeding of wild animals on record.
Many, perhaps, will see an additional cause in teleological considerations, aiming at the avoidance of in-and-in breeding.

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