| For example, a patient taking neuroleptics who relapses to stimulant medications is at risk of hyperpyrexia. |
| A fatal issue is most frequently observed in connection with hyperpyrexia alone, or in combination with delirium or coma. |
| Hypertensive crises, hyperactivity, hyperpyrexia, spasticity, severe convulsions or coma, and death have been reported in patients receiving such combinations. |
| In addition, the concomitant use of a codeine-containing product and monoamine oxidase inhibitors can occasionally result in symptoms such as hyperpyrexia, arrhythmia, myoclonus or coma. |
| Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability. |
| A variety of neurological toxic effects and malignant hyperpyrexia can occur, sometimes with fatal results. |
