| The dashed vertical line indicates the end of the amino terminus and the beginning of the helicase domain. |
| Dr. Guarente and his colleagues showed that when the yeast helicase gene is disrupted, the yeast cells become more sensitive to the waste circles and age prematurely. |
| The DNA to be copied enters the whirling blue molecular machine, called helicase, which spins it as fast as a jet engine as it unwinds the double helix into two strands. |
| The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. |
| In certain cases, the combination of a helicase and a topoisomerase provides a unique biological function and the interaction between the two is evolutionarily conserved. |
| Observing single mechanistic cycle of a helicase is crucial to understanding how it utilizes its fuel to generate mechanical forces. |
