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What does go up in flames mean?

Looking for the meaning or definition of the word go up in flames? Here's what it means.

Verb
  1. (idiomatic) To be cancelled or ruined without any hope of return.
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Examples
Should we wait until we get situations like those in Italy, where entire camps go up in flames?
In the aftermath of a collision cars with full fuel tanks tend to go up in flames killing the occupants who might have survived the collision.
The western part of the city in particular has been constantly pounded by Russian artillery, and factories and apartment blocks go up in flames after air raids.
The body of Leclair was recognizable because of his long beard, which miraculously did not go up in flames.
Incadescent sculpture is putting on a bed of wood shavings and go up in flames.
If, heaven forbid, his home and studio were to go up in flames, after his beloved wife what would he save?

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