A similar trend was observed for succinate, and for malate plus glutamate oxidation, by digitonin-permeabilized fibroblasts. |
We favor cytokine-and growth factor-dependent transdifferentiation of resident fibroblasts into myofibroblasts. |
For example, bronchial epithelial cells exposed to a compressive stress in vitro elicit a profibrotic response in unstressed fibroblasts. |
A dense band of fibroblasts, collagen fibers, proteoglycans, and occasional mast cells encase the granuloma. |
The adventitia is rich in collagen bundles, and contains some cells that may be fibroblasts or macrophages. |
To include a test system avoiding this general problem, primary human embryonic fibroblasts were added to the study. |