| The primary safety endpoints included symptomatic intracranial bleeding, major extracranial bleeding and all-cause mortality. |
| Extracranial headaches may be caused by dilation and distension of the extracranial arteries that supply the surface tissues of the head or sustained contraction of the skeletal muscles of the face, scalp, and neck. |
| Despite having an increase risk of major gastrointestinal or other major extracranial bleeds, the benefits of antiplatelet therapy for secondary prevention substantially exceed the risks. |
| The extracranial findings include opacification of the mastoid air cells with resultant suppuration. |
| Patients with extracranial tumours or lesions may need to have metallic markers implanted to target the area and guide treatment. |
| Brain-stem death may also arise as an intracranial consequence of extracranial events. |
