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What does cardiotoxicity mean?

Looking for the meaning or definition of the word cardiotoxicity? Here's what it means.

Noun
  1. The state or condition of being cardiotoxic.
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The second mechanism of TCA cardiotoxicity involves the blockade of norepinephrine uptake at the adrenergic presynaptic endings.
Adriamycin is used as a broad spectrum anticancer drug, but its irreversible cardiotoxicity greatly limits its clinical applications.

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