| Many of these studies have used albuterol-induced bronchodilation as the pharmacodynamic response measured. |
| Clearly, when testing for bronchodilation, there needs to be bronchodilation demonstrable and different degrees of this. |
| In patients, salmeterol by both pressurised and powder inhalers in single doses of 25 mcg or greater has been shown to produce bronchodilation lasting for approximately 12 hours. |
| Phase II studies have been successfully completed and results demonstrated that fixed dose combination QVA149 provided superior bronchodilation compared to QAB149 or placebo, which was sustained over 24 hours. |
| Albuterol-induced bronchodilation is another suitable pharmacodynamic response in that it mimics clinical use as treatment for bronchospasm that is already present. |
| In addition to steroids, albuterol should be used for bronchodilation because of its short onset of action. |
