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What is an apoenzyme?

What is an apoenzyme? Here are some definitions.

Noun
  1. (biochemistry) An inactive haloenzyme lacking a cofactor.
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Examples
In the case of PNPO deficiency, plasma AADC activity can be increased, probably owing to upregulation of apoenzyme synthesis in the absence of the PLP cofactor.
During preincubation the apoenzyme and hematin form the active holoenzyme.
Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure.
A cofactor that is bound loosely to the apoenzyme and can be readily separated from it is called a coenzyme.

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