Atryn aims to prevent excessive blood clots in patients with a disorder known as hereditary antithrombin deficiency. |
Pre-albumin, C1-esterase inhibitor, haptoglobins, transferrin, antithrombin III, prothrombin and plasminogen were all shown to increase following administration of danazol. |
To make its protein, GTC took the human gene for antithrombin and linked it to goat DNA that normally controls production of a protein found in milk. |
The antithrombin assay uses a chromogenic method and follows similar manufacturer instructions. |
Patients with antithrombin deficiency or homozygous FVL need life long anticoagulation after a first VTE event due to high recurrence risk. |
The drug was approved to prevent blood clots in people born with a rare hereditary deficiency of antithrombin while they undergo surgery or childbirth. |