| Transient leukopenia, neutropenia, agranulocytosis, thrombocytopenia and lymphocytosis were very rarely seen. |
| Bone marrow biopsy and other hematologic tests were consistent with agranulocytosis and marked erythroid hypoplasia of the megakaryocyte type. |
| Several cases of agranulocytosis and neutropenia have been reported in which a causal relationship to enalapril cannot be excluded. |
| Due to a significant risk of agranulocytosis, patients on clozapine and their treating physicians and dispensing pharmacists have to be enrolled in registries, which are currently specific to each market authorization holder. |
| With clozapine, a major limitation of its use is the high incidence of agranulocytosis. |
| Hematologic Reactions: Leukopenia, agranulocytosis, hemolytic anemia, thrombocytopenia, aplastic anemia, erythrocytopenia, granulocytopenia, and pancytopenia have been reported with sulfonylureas, including glimepiride. |
