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What is an adverse effect?

What is an adverse effect? Here are some definitions.

Noun
  1. Side-effect, especially a negative one in pharmacology.
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Examples
The predominant adverse effect seemed to be depression of the central nervous system.
The adverse effect immediately made an impact on the company's financial performance.
Untreated maternal depression, on the other hand, may have an adverse effect on development.
In the case of depilation, the applied cream may be antiseptic, and skin irritation may be an adverse effect.
Roadworks on three of the routes in and out of Skipton are having an adverse effect on local businesses.
It is submitted that a criminal conviction would have a serious adverse effect on a promising career.

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