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What is an adverse effect?

What is an adverse effect? Here are some definitions.

Noun
  1. Side-effect, especially a negative one in pharmacology.
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Examples
This method always involved having at least three water knots along the leader, it never really seemed to have an adverse effect.
The authors conclude that encouraging parents to view and hold stillborn infants does not benefit mothers and could have an adverse effect.
The increased keel weight would have an adverse effect on speed, fuel efficiency, rig safety, freeboard, and safe capacity.
It is submitted that a criminal conviction would have a serious adverse effect on a promising career.
Roadworks on three of the routes in and out of Skipton are having an adverse effect on local businesses.
Untreated maternal depression, on the other hand, may have an adverse effect on development.

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